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(Sharecast News) - London's FTSE 100 was down 2.6% at 7,707.53 in afternoon trade on Wednesday.
Pharma giants GSK and AstraZeneca both fell sharply after Trump said on Tuesday that the US would soon announce a "major" tariff on pharmaceutical imports.
JD Sports shot to the top of the index as it said that full-year profits were set to be in line with previous guidance and announced the launch of a £100m share buyback.
The company said trading to the end of March has been as it expected. For FY25, the group expects organic revenue growth of 5.8% and profit before tax and adjusting items in line with January guidance of £915m to £935m.
For FY26, JD currently expects profit before tax and adjusting items to be in line with consensus expectations of between £878m and £982m, but this excludes any potential impact from changes to tariffs.
Precious metals miner Fresnillo shone as gold prices advanced amid a flight to safety.
FTSE 100 - Risers
JD Sports Fashion (JD.) 68.74p 8.83%
Fresnillo (FRES) 869.50p 0.87%
Airtel Africa (AAF) 148.00p 0.20%
RELX FINANCE BV 3.375% GTD NTS 20/03/33 (BW73) 99.72p 0.00%
Next (NXT) 11,000.00p -0.14%
BAE Systems (BA.) 1,563.00p -0.22%
Auto Trader Group (AUTO) 727.00p -0.41%
Diageo (DGE) 2,030.00p -0.64%
BT Group (BT.A) 150.20p -0.73%
3i Group (III) 3,518.00p -0.76%
FTSE 100 - Fallers
AstraZeneca (AZN) 9,641.00p -7.07%
Intermediate Capital Group (ICG) 1,550.00p -6.12%
GSK (GSK) 1,258.50p -6.12%
BP (BP.) 333.50p -5.86%
Schroders (SDR) 285.60p -5.74%
Melrose Industries (MRO) 383.20p -5.73%
Land Securities Group (LAND) 494.60p -5.25%
Smurfit Westrock (DI) (SWR) 2,946.00p -4.94%
Scottish Mortgage Inv Trust (SMT) 815.80p -4.81%
Persimmon (PSN) 1,090.50p -4.80%